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SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 16 Reviews
8.4
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
Vitamin B12 helps heart recovery
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Directly addresses vitamin B12 effects
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
7
Vitamin B12 may reduce inflammation
Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice.
Direct evaluation of heart disease factors.
We explored the connection between vitamin B12 levels and inflammatory markers in individuals at high risk for heart disease. Our research focused on a group of 136 people, examining how their vitamin B12 correlated with levels of interleukin (IL)-6 and C-reactive protein (CRP), both important indicators of inflammation tied to heart health.
Findings revealed that participants with higher levels of vitamin B12 had lower concentrations of IL-6 and CRP even after we accounted for other influencing factors. To ensure that the results were reliable, we also replicated the analysis in naturally aged mice, where we found a similar trend—higher vitamin B12 seemed to correspond with lower IL-6 levels.
These results suggest that vitamin B12 may play a role in reducing inflammation, which is a significant risk factor for heart disease. While this study does not definitively prove that vitamin B12 supplementation can prevent heart disease, it does highlight a potential link that warrants further investigation.
Findings revealed that participants with higher levels of vitamin B12 had lower concentrations of IL-6 and CRP even after we accounted for other influencing factors. To ensure that the results were reliable, we also replicated the analysis in naturally aged mice, where we found a similar trend—higher vitamin B12 seemed to correspond with lower IL-6 levels.
These results suggest that vitamin B12 may play a role in reducing inflammation, which is a significant risk factor for heart disease. While this study does not definitively prove that vitamin B12 supplementation can prevent heart disease, it does highlight a potential link that warrants further investigation.
Read More
7
Vitamin B12 and heart health
Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders.
Relevance suggests moderate research impact
We explored the possible connection between vitamin B12 and heart disease, focusing on its role in the cardiovascular system. This vitamin is essential for various bodily functions, including DNA synthesis and energy production. Vegans and others lacking in animal products might face a higher risk of deficiency, which could potentially impact heart health and other vital areas.
Interestingly, we observed that alongside common treatments like statins for cardiovascular disease (CVD) prevention, there's been a growing interest in using vitamin B12 with other B vitamins like folate and B6. Current research suggests that managing homocysteine levels, an amino acid linked to heart health, could be helped by vitamin B12 supplementation. However, it is important to note that while there is promising information about the benefits of vitamin B12, the specific effects when isolated from other B vitamins remain less clear.
With chronic conditions such as Chronic Kidney Disease (CKD) also raising cardiovascular risks, regular monitoring of vitamin B12 levels may be beneficial for detecting deficiencies early and helping to prevent heart-related diseases. Overall, while vitamin B12 can play a significant role in heart health, further studies are needed to fully understand its potential impacts compared to other treatments.
Interestingly, we observed that alongside common treatments like statins for cardiovascular disease (CVD) prevention, there's been a growing interest in using vitamin B12 with other B vitamins like folate and B6. Current research suggests that managing homocysteine levels, an amino acid linked to heart health, could be helped by vitamin B12 supplementation. However, it is important to note that while there is promising information about the benefits of vitamin B12, the specific effects when isolated from other B vitamins remain less clear.
With chronic conditions such as Chronic Kidney Disease (CKD) also raising cardiovascular risks, regular monitoring of vitamin B12 levels may be beneficial for detecting deficiencies early and helping to prevent heart-related diseases. Overall, while vitamin B12 can play a significant role in heart health, further studies are needed to fully understand its potential impacts compared to other treatments.
Read More
Most Useful Reviews
9.5
Essential daily intake
Everyone needs vitamin B12 daily, as it supports numerous body functions. Symptoms of deficiency include fatigue and heart problems. I prefer Now Foods Methyl B-12 for its taste and effectiveness, especially since I avoid animal products.
Read More
9.5
Supports heart health
I sought an effective way to support my energy and nervous system, and this vitamin B12 is perfect. The methylcobalamin boosts my energy levels, supports nerve health, and is easily absorbed. It also helps maintain metabolism and reduces homocysteine, important for heart disease. Its antioxidant properties support overall health, and regular use enhances my mood and well-being.
Read More
8.8
Aids nerve health
Methylcobalamin is better absorbed than cyanocobalamin and aids in nerve regeneration, benefiting conditions like Alzheimer's and Parkinson's. At 1000mcg, the dosage is safe and effective. The tablets are small and sweet, designed to melt in your mouth.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
9
Vitamin B12 helps heart recovery
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Directly addresses vitamin B12 effects
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
7
Vitamin B12 may reduce inflammation
Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice.
Direct evaluation of heart disease factors.
We explored the connection between vitamin B12 levels and inflammatory markers in individuals at high risk for heart disease. Our research focused on a group of 136 people, examining how their vitamin B12 correlated with levels of interleukin (IL)-6 and C-reactive protein (CRP), both important indicators of inflammation tied to heart health.
Findings revealed that participants with higher levels of vitamin B12 had lower concentrations of IL-6 and CRP even after we accounted for other influencing factors. To ensure that the results were reliable, we also replicated the analysis in naturally aged mice, where we found a similar trend—higher vitamin B12 seemed to correspond with lower IL-6 levels.
These results suggest that vitamin B12 may play a role in reducing inflammation, which is a significant risk factor for heart disease. While this study does not definitively prove that vitamin B12 supplementation can prevent heart disease, it does highlight a potential link that warrants further investigation.
Findings revealed that participants with higher levels of vitamin B12 had lower concentrations of IL-6 and CRP even after we accounted for other influencing factors. To ensure that the results were reliable, we also replicated the analysis in naturally aged mice, where we found a similar trend—higher vitamin B12 seemed to correspond with lower IL-6 levels.
These results suggest that vitamin B12 may play a role in reducing inflammation, which is a significant risk factor for heart disease. While this study does not definitively prove that vitamin B12 supplementation can prevent heart disease, it does highlight a potential link that warrants further investigation.
Read More
7
Vitamin B12 and heart health
Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders.
Relevance suggests moderate research impact
We explored the possible connection between vitamin B12 and heart disease, focusing on its role in the cardiovascular system. This vitamin is essential for various bodily functions, including DNA synthesis and energy production. Vegans and others lacking in animal products might face a higher risk of deficiency, which could potentially impact heart health and other vital areas.
Interestingly, we observed that alongside common treatments like statins for cardiovascular disease (CVD) prevention, there's been a growing interest in using vitamin B12 with other B vitamins like folate and B6. Current research suggests that managing homocysteine levels, an amino acid linked to heart health, could be helped by vitamin B12 supplementation. However, it is important to note that while there is promising information about the benefits of vitamin B12, the specific effects when isolated from other B vitamins remain less clear.
With chronic conditions such as Chronic Kidney Disease (CKD) also raising cardiovascular risks, regular monitoring of vitamin B12 levels may be beneficial for detecting deficiencies early and helping to prevent heart-related diseases. Overall, while vitamin B12 can play a significant role in heart health, further studies are needed to fully understand its potential impacts compared to other treatments.
Interestingly, we observed that alongside common treatments like statins for cardiovascular disease (CVD) prevention, there's been a growing interest in using vitamin B12 with other B vitamins like folate and B6. Current research suggests that managing homocysteine levels, an amino acid linked to heart health, could be helped by vitamin B12 supplementation. However, it is important to note that while there is promising information about the benefits of vitamin B12, the specific effects when isolated from other B vitamins remain less clear.
With chronic conditions such as Chronic Kidney Disease (CKD) also raising cardiovascular risks, regular monitoring of vitamin B12 levels may be beneficial for detecting deficiencies early and helping to prevent heart-related diseases. Overall, while vitamin B12 can play a significant role in heart health, further studies are needed to fully understand its potential impacts compared to other treatments.
Read More
4
Vitamin B12 deficiency and heart disease
Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation.
Limited effect of vitamin B12
We explored a unique case involving a young man diagnosed with Cobalamin C deficiency, a rare genetic condition affecting vitamin B12 metabolism. This condition can lead to serious health issues, including structural heart defects and severe heart failure.
Throughout his life, the patient received multiple treatments for his deficiency, including vitamin B12 supplements. However, he eventually developed severe heart failure due to dilated cardiomyopathy. Despite earlier improvements from medical treatments, his heart condition worsened, requiring advanced interventions such as a left ventricular assist device (LVAD) and ultimately a heart transplant.
Although vitamin B12 played a role in his overall treatment regime, the real focus was on managing his severe heart failure through these significant medical interventions. This case, unprecedented in its combination of LVAD implantation and heart transplant for someone with Cobalamin C deficiency, demonstrates that while vitamin B12 is essential, it is the advanced cardiac procedures that addressed the dire heart condition effectively.
In short, while vitamin B12 may improve symptoms of deficiency, advanced heart failure requires intensive medical strategies that go beyond vitamin supplementation alone.
Throughout his life, the patient received multiple treatments for his deficiency, including vitamin B12 supplements. However, he eventually developed severe heart failure due to dilated cardiomyopathy. Despite earlier improvements from medical treatments, his heart condition worsened, requiring advanced interventions such as a left ventricular assist device (LVAD) and ultimately a heart transplant.
Although vitamin B12 played a role in his overall treatment regime, the real focus was on managing his severe heart failure through these significant medical interventions. This case, unprecedented in its combination of LVAD implantation and heart transplant for someone with Cobalamin C deficiency, demonstrates that while vitamin B12 is essential, it is the advanced cardiac procedures that addressed the dire heart condition effectively.
In short, while vitamin B12 may improve symptoms of deficiency, advanced heart failure requires intensive medical strategies that go beyond vitamin supplementation alone.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.4
10
Relieves pain
I experienced bone pain and fatigue from vitamin deficiency. After taking B-12, my condition improved significantly.
9.5
Essential daily intake
Everyone needs vitamin B12 daily, as it supports numerous body functions. Symptoms of deficiency include fatigue and heart problems. I prefer Now Foods Methyl B-12 for its taste and effectiveness, especially since I avoid animal products.
9.5
Supports heart health
I sought an effective way to support my energy and nervous system, and this vitamin B12 is perfect. The methylcobalamin boosts my energy levels, supports nerve health, and is easily absorbed. It also helps maintain metabolism and reduces homocysteine, important for heart disease. Its antioxidant properties support overall health, and regular use enhances my mood and well-being.
Read More
8.8
Aids nerve health
Methylcobalamin is better absorbed than cyanocobalamin and aids in nerve regeneration, benefiting conditions like Alzheimer's and Parkinson's. At 1000mcg, the dosage is safe and effective. The tablets are small and sweet, designed to melt in your mouth.
8.8
Reduces hypertension
The product arrived quickly. B-12 tablets are small and easy to use. B-12 plays an essential role in metabolic processes, including reducing homocysteine levels, which can lead to hypertension and heart failure if deficient.
